Antimicrobial Activities of Novel Bis-Piperidinium Compounds.
نویسندگان
چکیده
The antimicrobial activity of two new series of bis-piperidinium compounds with alkyl chains of different lengths against bacterial (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis) and fungal strains (Aspergillus flavus, Aspergillus niger, Rhodolorula rubera, Lipomyces lopofera and Candida albicans), are described. Antimicrobial activities of the synthesized compounds were compared to that of dodecyltrimethylammonium chloride. Bis-piperidinium salts possessing 12-16 carbon side chains showed better antimicrobial properties as compared to the standard dodecyltrimethylammonium chloride.
منابع مشابه
Synthesis, In vitro Antimicrobial and Cytotoxic Activities of Some Novel Bis- 1, 3, 4-oxadiazoles
A series of novel bis-1,3,4-oxadizaoles were synthesized by oxidative cyclisation of respective Schiff bases derived from dicarbohydrazide using ceric ammonium nitrate (CAN) as catalyst. The synthesized compounds were screened for in vitro antibacterial activity against Staphylococcus aureus (MTCC 87), Escherichia coli (MTCC 46) and antifungal activity against Candida albicans (NCIM 3471) by tw...
متن کاملPreparation, Characterisation and Antimicrobial Activities of Some Novel Nitriles and Imidazolines
Reaction between 5-methyl-3-aminoisoxazole and ?-acetamidophenylsulpho-nylchloride yielded compound 1. Hydrolysis of compound 1 gave a starting compound 4-methoxybenzal-?-5-methyl isoxazol-3-yl-sulphonamido aniline 2. The compound 2 on condensation with different aldehydes and potassium cyanide yielded the nitriles 3a-l. Cyclocondensation between oxazolinone and compound 2 yielded imidazolines ...
متن کاملAntimicrobial activity of N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides.
The aim of the study was to assay antibacterial and antifungal activity of newly synthesised N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides. The compounds tested were found to inhibit the growth of some Gram-negative bacteria, Gram-positive strains and some representatives of yeast-type Candida. From microbiological experiments two of the compounds tested, N-dodecyloxycarbonylmethyl-N-me...
متن کاملQSAR modeling of antimicrobial activity with some novel 1,2,4 triazole derivatives, comparison with experimental study
Our study performed upon an extended series of 28 compounds of 1,2,4-triazole derivatives that demonstrate substantial in vitro antimicrobial activities by serial plate dilution method, using quantitative structure-activity relationship (QSAR) methods that imply analysis of correlations and multiple linear regression (MLR); a significant collection of molecular descriptors was used e.g., Edge a...
متن کاملIsolation and Characterisation of Actinobacteria from Algerian Sahara Soils with Antimicrobial Activities
Extreme ecosystems can be a source of untapped micro-organisms able to produce novel bioactive compounds of industrial interest. Consequently, in this work, 32 Actinomycetes were isolated from 6 soil samples collected from Algerian Sahara in searching for untapped producers of novel antimicrobial compounds. All the isolates were further subjected to antimicrobial screening against pathogenic ba...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Polish journal of microbiology
دوره 61 3 شماره
صفحات -
تاریخ انتشار 2012